Alendronate is a bisphosphonate that binds to bone hydroxyapatite and exclusively inhibits the activity of osteoclasts, the bone-resorbing cells.Alendronate inhibits osteoclast-mediated bone-resorption. Like all bisphosphonates, it is actually chemically linked to inorganic pyrophosphate, the endogenous regulator of bone turnover. But while pyropho